ACT NOW AGAINST 

ANTIBIOTIC RESISTANCE

YOUR CHOICES TODAY COULD
TRANSFORM YOUR TOMORROWS

protect

Not an actual patient
ring

A global health crisis

Lead the way in the fight against resistance

From the moment they were discovered, antibiotics have transformed medicine, and saved millions of lives1

However, the rapid emergence of antibiotic resistance is threatening the very existence of these life-saving drugs, and their benefit to you, and your patients.1 Meaning, considering the right drug, dose and duration is now more essential than ever in tackling this health crisis2,3 

With dermatology being the top antibiotic prescriber specialty in the U.S., you are uniquely positioned to take the lead in what has become a global fight against antibiotic resistance5–7

By continuing to uphold your responsibility to antibiotic stewardship, you can help protect the future of these vital medicines for generations to come2,8

Read More

10 million lives

Antibiotic resistance is on track to claiming 10 million lives a year by 2050. That is 10 million people dying from previously-treatable bacterial infections4

Your choices today, could transform 
their tomorrows

Antibiotic resistance has now become a universal threat. It can affect anyone, of any age, in any country, making us all key in the fight against it6,9

Act now against antibiotic resistance10

Right drug

Right drug

+

Right dose

Right dose

+

Right duration

Right duration

=

protect

ring

Without action

Without effective antibiotics, currently safe procedures like organ transplantations, chemotherapy, and
surgeries become life-threatening, and other infectious diseases may become difficult to treat. Without a
real change in prescribing behavior, we are putting the achievements of
modern medicine, and the lives of many, at risk2,5

group

In the U.S. alone, each year at least 2.8 million people get an antibiotic-resistant infection2

money

Economic losses of about $35 billion annually have been recorded, related to lost productivity, due to antibiotic resistances in U.S. healthcare systems alone11

threats

Methicillin-resistant Staphylococcus aureus (MRSA) infections alone, among the highest of all antibiotic-resistance threats, are said to cost the U.S. healthcare system ~$60,000 per patient and ~$9.7 billion a year12

ANTIBIOTIC MISUSE

The problem we are facing is real

Without a real change in prescribing behavior, we risk the effectiveness of our antibiotics2,5
What are currently safe medical procedures, could become life-threatening2,5

Did you know, in the U.S.:

8.2 mil

oral antibiotic prescriptions are prescribed for dermatological conditions every year, with dermatologists prescribing antibiotics more commonly than any other physician group6

75%

of all oral antibiotics prescribed by dermatologists are tetracyclines, particularly doxycycline and minocycline6

20%

of patients prescribed antimicrobials in dermatology are individuals with acne or rosacea5

Without urgent action, antibiotic resistance could claim 
10 million lives a year by 20504

The science behind antibiotic resistance

Need for change

Everyone who depends on antibiotics must join forces to help detect and prevent the emergence, and spread of antibiotic resistance

The world urgently needs to change the way it prescribes and uses antibiotics – without behavior change, antibiotic resistance will not only remain a major threat, but an active reality2,4,9

Combating antibiotic resistance is not just a national, but a global priority, with the U.S. government, Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) all actively launching initiatives, supporting research and outlining guidance, with hopes to tackle the devastating threat that antibiotic resistance poses2,18,19

“Fighting this threat is a public health priority. It requires a collaborative global approach across sectors to detect, prevent, and respond to these threats when they occur”

Centers for Disease Control and Prevention (CDC), 202018

As part of the ongoing battle against resistance in the U.S., the CDC proposed core actions to better prepare the nation for this threat that continues to emerge worldwide – antibiotic stewardship is an integral cornerstone in this strategy:2,8

Treatment Slider

1

Infection prevention and control

Prevent infections and their spread by continuing to follow infection prevention and control guidelines

2

Tracking and data

Share data, and improve data collection around infection patterns while staying informed of current resistant outbreaks/trends

3

Antibiotic use and access

Improve appropriate use of antibiotics, reduce unnecessary use (antibiotic stewardship), and ensure improved access to antibiotics

4

Vaccines, therapeutics, and diagnostics

Invest in development, and improved access to vaccines, therapeutics, and diagnostics for better prevention, treatment, and detection

5

Environment and sanitation

Keep antibiotics, and antibiotic-resistant threats from entering the environment through actions like improving sanitation and access to safe water

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You can confidently take the lead as an antibiotic steward in your field, by simply ensuring that the right drug, dose and duration is prescribed to your patients10,20

Not actual patients
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Act now against antibiotic resistance

Real change starts with you. Choose the right drug, dose and duration

With first-hand experience of the life-changing impact antibiotics can have on patients, and with dermatology being the top antibiotic prescriber specialty in the U.S., you are key in leading the global fight against antibiotic resistance6

Antibiotic stewardship can be used across all healthcare settings, and is the cornerstone of efforts in improving antibiotic use, and slowing the spread of resistance. The goal is to maximize the benefit of antibiotic treatment while minimizing harm both to individuals, and to communities10

What is antibiotic stewardship?

Antibiotic stewardship is the effort to measure and improve how antibiotics are prescribed by:10

  • Ensuring the right drug, dose and duration are selected when an antibiotic is needed
  • Prescribing and using antibiotics only when needed
  • Minimizing misdiagnoses or delayed diagnoses leading to underuse of antibiotics

Centers for Disease Control and Prevention (CDC), 202010

Read More

One change in how you prescribe, is one step further in the fight against resistance:6,15

  • Identify and assess whether an antibiotic is truly needed
  • Consider sub/non-antibiotic alternatives where possible 
  • Consider the shortest regimen required to treat

Continue to ask your patients if they have been on an antibiotic (what dose and duration) in the past 12 months to avoid cumulative effects of any medication

Take action against antibiotic resistance

Aside from opting for the right drug, dose and duration, there are
more ways you can uphold your commitment to antibiotic stewardship,
and help decelerate the threat in this fight against antibiotic
resistance10,21

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By considering sub-antibiotic dose treatments, you are not only offering your patients effective options, but also choosing to protect future health by opting for a treatment that does not contribute to antibiotic resistance20,23

Not actual patients
 a film role-style banner  of different type of people  a film role-style banner  of different type of people  a film role-style banner  of different type of people

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Important Safety Information

Indication: ORACEA® (doxycycline, USP) 40 mg* Capsules are indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. ORACEA Capsules do not lessen the facial redness caused by rosacea. Adverse Events: In controlled clinical studies, the most commonly reported adverse events (>2%) in patients treated with ORACEA Capsules were nasopharyngitis, sinusitis, diarrhea, hypertension and aspartate aminotransferase increase. Warnings/Precautions: ORACEA Capsules should not be used to treat or prevent infections. ORACEA Capsules should not be taken by patients who have a known hypersensitivity to doxycycline or other tetracyclines. ORACEA Capsules should not be taken during pregnancy, by nursing mothers, or during tooth development (up to the age of 8 years). Although photosensitivity was not observed in clinical trials, ORACEA Capsules patients should minimize or avoid exposure to natural or artificial sunlight. The efficacy of ORACEA Capsules treatment beyond 16 weeks and safety beyond 9 months have not been established

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088

*30 mg immediate release and 10 mg delayed release beads

REFERENCES

1. Ventola CL. The antibiotic crisis. Part 1: Causes and threats. P&T 2015;40:277–283. 2. Centers for Disease Control and Prevention 2020. Antibiotic resistances threats in the United States 2019. Available at: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf. Last accessed: September 2021 3. Paterson IK, et al. Optimising antibiotic usage to treat bacterial infections. Scientific Reports 2016;6:37853. DOI: https://doi.org/10.1038/srep37853.  4. World Health Organization 2019. No time to wait: Securing the future from drug-resistant infections. Available at: https://www.who.int/publications/i/item/no-time-to-wait-securing-the-future-from-drug-resistant-infections. Last accessed: September 2021. 5. Karadag AS, et al. Antibiotic resistance in acne: Changes, consequences and concerns. JEADV. 2020. https://doi.org/10.1111/jdv.16686. 6. Del Rosso JQ, et al. Status report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 1. J Clin Aesthet Dermatol. 2016;9(4):18–24. 7. Barbieri JS, et al. Trends in oral antibiotic prescription in dermatology, 2008 to 2016. JAMA Dermatol. 2019;155:290–297. 8. Centers for Disease Control and Prevention 2020. Antibiotic resistance questions and answers. Available at: https://www.cdc.gov/antibiotic-use/community/about/antibiotic-resistance-faqs.html. Accessed: September 2021. 9. World Health Organization 2020. Antibiotic resistance. Available at: https://www.who.int/news-room/fact-sheets/detail/antibiotic-resistance. Last accessed: September 2021. 10. Centers for Disease Control and Prevention 2019. The core elements of outpatient antibiotic stewardship. Available at: https://www.cdc.gov/antibiotic-use/community/pdfs/16_268900-A_CoreElementsOutpatient_508.pdf. Last accessed: September 2021. 11. Aslam B, et al. Antibiotic resistance: A rundown of a global crisis. Infection and Drug Resistance 2018;11:1645–1658. 12. Infection Control Today 2015. MRSA: The superbug poised to cost hospitals super sums. Available at: https://www.infectioncontroltoday.com/view/mrsa-superbug-poised-cost-hospitals-super-sums. Last accessed: September 2021. 13. Centers for Disease Control and Prevention 2020. How antibiotic resistances happens. Available at: https://www.cdc.gov/antibiotic-use/week/pdfs/How_Antibiotic_Resistance_Happens_508.pdf. Accessed: September 2021. 14. Antibiotic Research UK. Antibiotic-resistant bacteria in healthcare. Available at: https://www.antibioticresearch.org.uk/about-antibiotic-resistance/antibiotic-resistant-bacteria-in-healthcare/. Last accessed: September 2021. 15. Del Rosso JQ, et al. Status report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 3. J Clin Aesthet Dermatol. 2016;9(6):17–24.  16. Garrett JPD and Margolis DJ. Impact of long-term antibiotic use for acne on bacterial ecology and health outcomes: A review of observational studies. Curr Derm Rep. 2012;1:23–28. 17. Antibiotic Research UK. About antibiotic-resistant skin and soft tissue infections. Available at: https://www.antibioticresearch.org.uk/find-support/skin-soft-tissue-infections/. Last accessed: September 2021. 18. Centers for Disease Control and Prevention 2020. Combat antimicrobial resistance globally. Available at: https://www.cdc.gov/drugresistance/intl-actvities.html. Accessed: September 2021. 19. Centers for Disease Control and Prevention 2019. U.S action to combat antibiotic resistance: A national priority. Available: https://www.antibioticresearch.org.uk/find-support/skin-soft-tissue-infections/. Last accessed: September 2021. 20. Schaller M, et al. State of the art: Systemic rosacea management. J Dtsch Dermatol Ges. 2016;14:29–37. 21. Centers for Disease Control and Prevention 2020. Protecting patients and stopping outbreaks. Available at: https://www.cdc.gov/drugresistance/us-activities.html. Last accessed: September 2021. 22. World Health Organization. Global Antimicrobial Resistance Surveillance System (GLASS). Available at: https://www.who.int/publications/i/item/global-antimicrobial-resistance-surveillance-system-(-glass)-report. Last accessed: September 2021. 23. Del Rosso JQ, et al. Status report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society: Part 2. J Clin Aesthet Dermatol. 2016;9(5):11–17