Important Safety Information

Indication: ORACEA® (doxycycline, USP) 40 mg* Capsules are indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. ORACEA Capsules do not lessen the facial redness caused by rosacea. Adverse Events: In controlled clinical studies, the most commonly reported adverse events (>2%) in patients treated with ORACEA Capsules were nasopharyngitis, sinusitis, diarrhea, hypertension and aspartate aminotransferase increase. Warnings/Precautions: ORACEA Capsules should not be used to treat or prevent infections. ORACEA Capsules should not be taken by patients who have a known hypersensitivity to doxycycline or other tetracyclines. ORACEA Capsules should not be taken during pregnancy, by nursing mothers, or during tooth development (up to the age of 8 years). Although photosensitivity was not observed in clinical trials,
ORACEA Capsules patients should minimize or avoid exposure to natural or artificial sunlight. The efficacy of ORACEA Capsules treatment beyond 16 weeks and safety beyond 9 months have not been established

You are encouraged to report negative side effects of prescription drugs to the FDA
Visit www.fda.gov/medwatch
or call 1-800-FDA-1088

*30 mg immediate release and 10 mg delayed release beads

“Before, I used to get really nervous about planning
days out in fear of waking up with bumps and
blemishes of rosacea”

NOW LOOK AT ME

Not an actual patient
ring ring

Treatment for rosacea

By continuing with ORACEA® (doxycycline, USP) 40 mg* Capsules every day, as prescribed, you can help take control over your bumps and blemishes of rosacea

It’s time to look beyond immediate symptom improvement and commit to minimizing your flare-ups by continuing your rosacea treatment as prescribed. Successfully identifying and managing your triggers, as well as setting achievable goals alongside your dermatologist, will help you achieve clearer skin

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Investigator's Global Scale Assessment (IGA) Scale 4- Severe rosacea - numerous small and large papules and pustules on womans face

Severe ROSACEA

IGA 4

Numerous small and/or large papules/pustules, severe erythema

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Investigator's Global Scale Assessment (IGA) Scale 3 - Moderate rosacea numerous small and large papules and pustules on womans face

Moderate rosacea

IGA 3

Several small or large papules/pustules, moderate erythema

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Investigator's Global Scale Assessment (IGA) Scale 2 - Mild rosacea few small and large papules and pustules on womans face womans face

Mild rosacea

IGA 2

Few small papules/pustules, mild erythema

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Investigator's Global Scale Assessment (IGA) Scale 1 - Almost clear of rosacea numerous very few papules and pustules on womans faceon womans face

Almost clear of rosacea

IGA 1

Very few small papules/pustules, very mild erythema present

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Investigator's Global Scale Assessment (IGA) Scale 0 - Clear of rosacea no inflammatory lesions present, no erythema

clear of rosacea

IGA 0

No inflammatory lesions present, no erythema

It’s time to look beyond immediate symptom improvement and commit to minimizing your flare-ups by continuing your rosacea treatment as prescribed. Successfully identifying and managing your triggers, as well as setting achievable goals alongside your dermatologist, will help you achieve clearer skin

Achieving my rosacea treatment goals
Not an actual patient
quote

“Achieving my rosacea treatment goals and properly managing my condition helps me feel excited about the future again – it’s liberating!”

HELP CONTROL YOUR ROSACEA

ROSACEA SKIN CARE TIPS

Alongside an effective treatment, gentle skin care and rosacea trigger avoidance can help manage your symptoms. Keeping a journal of what you eat, drink, and when your rosacea flares, can help you discover and manage your triggers

An effective prescription treatment like ORACEA Capsules, which you only have to take once a day, can help control your bumps and blemishes of rosacea, leaving you with time to enjoy the rest of your day

GENERAL THINGS TO AVOID:

Cleansers with harsh soaps or alcohol

Cleansers with harsh soaps or alcohol

 Rough washcloths, brushes, or sponges

Rough washcloths, brushes, or sponges

 Exposure to direct sunlight on the face

Exposure to direct sunlight on the face

 Waterproof cosmetics or heavy foundations that require scrubbing

Waterproof cosmetics or heavy foundations that require scrubbing

HABITS TO PRACTICE:

 Use fragrance-free products—they have less potential for irritating skin

Use fragrance-free products—they have less potential for irritating skin

 Cleansers with harsh soaps or alcohol

Blot skin dry with a soft cotton towel after washing

 Use a broad-spectrum facial sunscreen daily

Use a broad-spectrum facial sunscreen daily

 Green-tinted makeup may help counter the redness of rosacea

Green-tinted makeup may help counter the redness of rosacea

About ORACEA Capsules

A once-daily treatment that may help you take
back control of your bumps and blemishes of
rosacea, safely and conveniently

A clearer future

Learn more about an effective rosacea
treatment that is safe for long-term
use

Rosacea Universe

Your go-to rosacea resource for
up-to-date information, news,
and insights

ORACEA Capsules are indicated for the treatment of only inflammatory lesions (bumps and blemishes) of rosacea in adult
patients. ORACEA Capsules do not lessen the facial redness caused by rosacea

To help get your rosacea on track, TALK TO YOUR DERMATOLOGIST ABOUT ORACEA CAPSULES

Get the most out of your conversation by recording your rosacea experiences here

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Important Safety Information

Indication: ORACEA® (doxycycline, USP) 40 mg* Capsules are indicated for the treatment of only inflammatory lesions (papules and pustules) of rosacea in adult patients. ORACEA Capsules do not lessen the facial redness caused by rosacea. Adverse Events: In controlled clinical studies, the most commonly reported adverse events (>2%) in patients treated with ORACEA Capsules were nasopharyngitis, sinusitis, diarrhea, hypertension and aspartate aminotransferase increase. Warnings/Precautions: ORACEA Capsules should not be used to treat or prevent infections. ORACEA Capsules should not be taken by patients who have a known hypersensitivity to doxycycline or other tetracyclines. ORACEA Capsules should not be taken during pregnancy, by nursing mothers, or during tooth development (up to the age of 8 years). Although photosensitivity was not observed in clinical trials, ORACEA Capsules patients should minimize or avoid exposure to natural or artificial sunlight. The efficacy of ORACEA Capsules treatment beyond 16 weeks and safety beyond 9 months have not been established

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088

*30 mg immediate release and 10 mg delayed release beads
Based on safety data from a 9-month clinical trial

REFERENCES

1. Del Rosso JQ, et al. Two randomized phase Ill clinical trials evaluating anti-inflammatory dose doxycycline (40-mg doxycycline, USP capsules) administered once daily for treatment of rosacea. J Am Acad Dermatol. 2007;56(5):791–802. 2. Del Rosso JQ, et al. Comparison of anti-inflammatory dose doxycycline versus doxycycline 100 mg in the treatment of rosacea. J Drugs Dermatol. 2008;7(8):573–576 3. Rosacea: Beyond the visible report. Available at: https://hosted.bmj.com/rosaceabeyondthevisible. Last accessed: September 2021 4. Preshaw PM, et al. Modified-release sub-antimicrobial dose doxycycline enhances scaling and root planning in subjects with periodontal disease. J Periodontol. 2008;79(3):440–452. 5. National Rosacea Society. (2020). All About Rosacea. Available: https://www.rosacea.org/patients/all-about-rosacea. Last accessed: September 2021 6. ORACEA [package insert]. Fort Worth, TX: Galderma Laboratories, L.P.; 2014